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For bone cancer, non-decalcified bone samples are required.
We are actively working with pathology labs to explore ways to preserve non-decalcified bone tissue, though this may require protocol adjustments and takes time.
We also encourage clinicians to freeze tumor tissue at the time of amputation whenever possible, as it can be valuable for both genomic analysis and immunotherapy.
In addition, when submitting histopath for potential bone cancer, we suggest including the note
“ATTENTION: Please save a portion of tumor tissue prior to decalcification for possible future genomic analysis.” In your submission note.